The park is the eastern extension of the vast Ituri Forest, forming part of the forest continuum from the Congo, the richest area for both flora and fauna in Africa. This reserve is also a rich mosaic of grassland and wetland habitats.
The fauna is correspondingly diverse, with the Uganda kob being the most common large mammal. There are also forest elephant, chimpanzees, buffalo, antelope, leopards and various monkey species. Of the 400 bird species recorded, the Shoebill Stork is regularly seen at close quarters on Lake Albert.